arXiv preprints from January 1, 2026 through September 5, 2026 — 14:06:37 EST
Reliable epidemic monitoring often requires inferring regional infection burden and transmission heterogeneity from noisy, spatially aggregated, and potentially sparse surveillance data. Agent-based models (ABMs) are attractive for this task because they represent individual behavior, contact heterogeneity, and localized...
Predicting transcriptional responses to specific perturbations is critical for understanding cellular regulatory mechanisms and accelerating drug discovery. Single-cell RNA sequencing destroys each measured cell, yielding only unpaired populations of control and perturbed cells. However, existing methods typically model perturbation...
When the rates of ligand binding are measured by methods such as surface plasmon resonance, it is common practice to use the observed rate constants for the onset and offset of binding to estimate an equilibrium constant for ligand binding. If this agrees with the equilibrium constant found as the EC50 for binding at equilibrium, this...
Here we present the Active Visual Semantics (AVS) dataset, a large-scale collection of magnetoencephalography (MEG) and eye-tracking data recorded while five participants freely explored 4,080 natural scenes over 10 sessions each, yielding more than 200,000 fixation epochs in total. Unlike existing neuroimaging datasets that rely on...
Token aggregation converts token-level representations into fixed-dimensional sample representations, but most pooling methods operate only in the original token space. We introduce Frequency-Domain Latent-attention Gated Pooling (FLaG), a plug-in aggregation module that re-expresses encoder outputs in the Fourier domain before final...
Geometric eigenmodes provide a compact and biologically grounded representation of large-scale neural activity. Previous work demonstrated that they can mitigate the underdetermined nature of electroencephalographic (EEG) and magnetoencephalographic (MEG) source localisation, an ill-posed inverse problem in which neural activity is...
Many natural and engineered systems are large complex networks of interacting components, and external perturbations drive them along different dynamical paths. Identifying which perturbation occurred matters for diagnosis, control, and prediction. Yet often times only a few components can be jointly monitored. Which components should...
Single-cell studies are typically initiated from predefined research questions, leaving much of the biological information encoded within existing data unexplored. We formalize open-ended discovery as an analytical paradigm, in which data-derived signals are identified before biological context is interrogated and subsequently...
Like pairwise distances, quartets can be highly redundant and correlated on a phylogenetic tree, and their number grows on the order of n^4 rather than n^2. I explore BME-like weights for reweighting quartet scores before summing them to score a full tree. Three weights are considered on an unrooted binary tree:...
At the water-land interface, amphibious fishes encounter wet flowable substrates made of granular solid-water mixtures, which can stay solid or flow like a fluid. As these substrates become wetter or drier, their yield strength (at which solid-fluid transition occurs) and cohesion (how sticky they are) both change, challenging...
Animals and robots encounter mud at the water-land interface. Like sand, mud can stay solid or flow like a fluid. Unlike sand, the yield strength of mud at which solid-fluid transitions occur depends on not only the amount of solid relative to fluid (water in mud, air in dry sand), but also how much coarse grains and fine clay are...
The corticothalamic circuit supports rhythms with timescales that differ by orders of magnitude: sleep spindles, the sigma-band events of non-rapid-eye-movement (NREM) sleep, and infra-slow fluctuations near 0.02Hz that organize when spindles occur. Because the anatomy is the same in both cases, architecture alone cannot determine...
Antibody-specific language models pretrained via masked language modeling (MLM) learn representations that are critical for downstream sequence design and property prediction tasks. Yet, the corruption process itself is rarely leveraged as a source of inductive bias during pretraining. While preferentially masking...
We study optimal sampling recovery in reproducing kernel Hilbert spaces (RKHS) in the uniform norm. For every RKHS with bounded kernel, we establish new comparisons between linear sampling widths and Gelfand widths that overcome the known square-root gap, without requiring a measure or a Christoffel-type condition. Our bounds rely on...
Let $X$ be a smooth complex projective variety of dimension $n$, and let $L$ be an ample Cartier divisor. We prove that $K_X+mL$ is globally generated for every integer $m\geq\lceil C_0n\rceil$, where $C_0=1.77629\ldots$ is an explicit constant. In particular, $K_X+2nL$ is globally generated. Our main input is a new estimate for the...
Fraenkel's conjecture asserts that a partition of the integers into at least three Beatty sequences with distinct moduli has the binary densities $1,2,4,\ldots,2^{m-1}$, normalized by $2^m-1$. We prove the conjecture through a dimension-free intermediate statement: every such partition contains a component of density at least 1/3....
In this note, we prove the existence of smooth complete admissible hypersurfaces in hyperbolic space with constant higher order mean curvature and a prescribed asymptotic boundary at infinity. Unexpectedly, our result holds for a large part of indices in the subcritical range where the concavity inequality loses its effectiveness. We...
For $n\in\mathbb{N}$, we consider the set of lattice paths from $(0,0)$ to $(n,n)$ using only unit north and east steps. Given a point $B$ to be avoided, we ask: at which point $A$ on the grid with corners $(0,0)$ and $(n,n)$, different from the endpoints, does the largest number of $B$-avoiding lattice paths pass through? We show...
We construct a bounded pseudoconvex complete Reinhardt domain $Ω$ with smooth boundary in $\mathbb{C}^3$ such that the $\bar\partial$-Neumann operator $N_1$ is compact although $bΩ$ contains an analytic disc and thus also fails Catlin's Property $(P)$ and McNeal's Property $(\tilde P)$. This example solves an open problem on...
In this paper, we study an Erlang-type loss system with energy-constrained servers. Each server is equipped with a finite battery and becomes temporarily unavailable for service when its energy is depleted, entering a charging phase before returning to operation upon full recharge. Customers who arrive to find all servers unavailable...
Let $H\in C^\infty(\mathbb R^n\times\mathbb T^n)$ be a periodic Tonelli Hamiltonian with critical value $c$. For each $k\in\mathbb N$, let $u_k$ be the normalized minimizer of the variational functional introduced by Evans[7], \[ I_k[w]=\int_{\mathbb T^n} e^{kH(Dw,x)}\,dx, \qquad \int_{\mathbb T^n}w\,dx=0. \] If $u_\infty$ is a...
Let $R$ be a commutative $\Q$-algebra and let $HR$ denote its Hurwitz series ring. We introduce a one-parameter convolution $\hconv{t}$ on $HR$ for which the specialization $t=-1$ is the intrinsic Hurwitz product. Positive integral parameters act on finite-support truncations and reproduce finite free convolution in coefficient...
This paper establishes necessary and sufficient conditions for locally flat knotted surfaces in simply-connected $4$-manifolds to be equivalent. For surfaces with knot group $\mathbb{Z}_d$, we extend results of Lee-Wilczynski from spheres to surfaces of arbitrary genus; the surfaces are permitted to be nonorientable and have boundary....
We prove that a coaction of a Hopf algebra on another preserving the latter's associative-algebra structure and comultiplication automatically also preserves the counit, antipode, and tensor-interchange map and in fact factors through the coaction dual to an action of an affine group scheme by Hopf-algebra automorphisms. This...
We extend the Dong-Song stability theorem for the Riemannian positive mass theorem to higher dimensional spin manifolds. More precisely, for a sequence of complete asymptotically flat spin n-manifolds with nonnegative scalar curvature and ADM masses tending to zero, the exterior regions obtained by excising domains whose boundary...