arXiv preprints from January 1, 2026 through September 22, 2026 — 03:07:09 EST
Clinical trials are notorious for their high failure rates and steep costs, leading to wasted time and resources spend, prolonged development timelines, and delayed patient access to new therapies. A key contributor to these failures is biological uncertainty, which complicates trial design and weakens the ability to detect true...
Assessing the validity of user simulators when used for the evaluation of information retrieval systems remains an open question, constraining their effective use and the reliability of simulation-based results. To address this issue, we conduct a comprehensive literature review with a particular focus on methods for the validation of...
Oculomics - the concept of predicting systemic diseases, such as cardiovascular disease and dementia, through retinal imaging - has advanced rapidly due to the data efficiency of transformer-based foundation models like RETFound. Image-level mixed sample data augmentations, such as CutMix and MixUp, are frequently used for training...
We calculate the permittivity, $ε(ω)$, for a medium with a quadratic electro-optic effect, modeling it as a Duffing oscillator. The nonlinear refractive index $n(ω, E(ω))$ and the nonlinear absorption coefficient $α(ω, E(ω))$ exhibit hysteresis when the light intensity is varied [here $E(ω)$ is the electric field strength at angular...
The use of structured matter, such as optical retarders, for vectorial control is a well-established and widely employed technique in modern optics, and has driven continued advances in the manipulation of complex, spatially varying vectorial fields. However, achieving arbitrary field conversion typically requires the use of cascaded...
Existing research highlights the crucial role of topological priors in image segmentation, particularly in preserving essential structures such as connectivity and genus. Accurately capturing these topological features often requires incorporating width-related information, including the thickness and length inherent to the image...
Hyperspectral image (HSI) deconvolution is a challenging ill-posed inverse problem, made difficult by the data's high dimensionality.We propose a parameter-parsimonious framework based on a low-rank Canonical Polyadic Decomposition (CPD) of the entire latent HSI $\mathbf{\mathcal{X}} \in \mathbb{R}^{P\times Q \times N}$.This approach...
Context: Technical lag accumulates when software systems fail to keep pace with technological advancements, leading to a deterioration in software quality. Objective: This paper aims to consolidate existing research on technical lag, clarify definitions, explore its detection and quantification methods, examine underlying causes and...
In the past decades, static analysis has thrived in software, facilitating applications in bug detection, security, and program understanding. These advanced analyses are largely underpinned by general-purpose static analysis frameworks, which offer essential infrastructure to streamline their development. Conversely, hardware lacks...
This paper investigates how end-to-end (E2E) channel autoencoders (AEs) can achieve energy-efficient wideband communications by leveraging Walsh-Hadamard (WH) interleaved converters. WH interleaving enables high sampling rate analog-digital conversion with reduced power consumption using an analog WH transformation. We demonstrate...
We investigate the orbital dynamics of four-planet systems consisting of Earth-mass planets on initially-circular, coplanar orbits around a star of one solar mass. In our simulations, the innermost planet's semimajor axis is set at 1 AU, with subsequent semimajor axes spaced equally in terms of planets' mutual Hill radii. Several sets...
Physics-Informed Neural Networks (PINNs) represent a groundbreaking paradigm in scientific computing, seamlessly integrating the robust framework of deep learning with fundamental physical laws. This paper meticulously applies the standard PINN framework to solve the challenging one-dimensional nonlinear Fisher-KPP equation, a...
Cascaded liquid crystal spatial light modulators provide a versatile strategy for the generation of structured light and matter fields, with applications including optical communications, photonic computing, and topological field engineering. However, experimental imperfections, such as temperature-dependent liquid crystal response,...
We present the first empirical derivation of a continuous-time stochastic model for real-world opinion dynamics. Using longitudinal social-media data to infer users opinion on a binary climate-change topic, we reconstruct the underlying drift and diffusion functions governing individual opinion updates. We show that the observed...
Vision-Language-Action models have emerged as essential generalist robot policies for diverse manipulation tasks, conventionally relying on directly translating multimodal inputs into actions via Vision-Language Model embeddings. Recent advancements have introduced explicit intermediary reasoning-such as sub-task prediction (language)...
Energy levels of QED bound states, which depend on a number of independent mass parameters, can be calculated as matrix elements of the QED energy-momentum tensor trace. As an example of such system we consider muonic hydrogen. The leading one-loop corrections to its energy levels depend on the electron and muon masses. These...
Surface defects on Printed Circuit Boards (PCBs) directly compromise product reliability and safety. However, achieving high-precision detection is challenging because PCB defects are typically characterized by tiny sizes, high texture similarity, and uneven scale distributions. To address these challenges, this paper proposes a novel...
Credit assignment is a core challenge in multi-agent reinforcement learning (MARL), especially in large-scale systems with structured, local interactions. Graph-based Markov decision processes (GMDPs) capture such settings via an influence graph, but standard critics are poorly aligned with this structure: global value functions...
Accurate wetland mapping is essential for ecosystem monitoring, yet dense pixel-level annotation is prohibitively expensive and practical applications usually rely on sparse point labels, under which existing deep learning models perform poorly, while strong seasonal and inter-annual wetland dynamics further render single-date imagery...
In the context of pre-processing -- a scenario in which galaxies quench their star formation within substructures before falling into clusters -- we investigate the impact of environment on the physical and morphological properties of galaxies in Compact Groups (CGs), focusing specifically on a sample of Star-Forming Compact Groups...
The complexity of navigating digital privacy, safety, and security threats often falls directly on users. This leads to users seeking help from family and peers, platforms and advice guides, dedicated communities, and even large language models (LLMs). As a precursor to improving resources across this ecosystem, our community needs to...
This work describes a novel data-driven latent space inference framework built on paired autoencoders to handle observational inconsistencies when solving inverse problems. Our approach uses two autoencoders, one for the parameter space and one for the observation space, connected by learned mappings between the autoencoders' latent...
3D semantic occupancy prediction has emerged as a critical perception task for autonomous driving due to its ability to offer voxel-level semantic and geometric understanding of the environment. However, such a refined representation for large-scale scenes incurs prohibitive computation, posing a significant challenge to practical...
We study deterministic nonstationary discrete-time optimal control problems in both finite and infinite horizon. With the aid of Gateaux differentials, we prove a discrete-time maximum principle in analogy with the well-known continuous-time maximum principle. We show that this maximum principle, together with a transversality...
The development of robust learning-based control algorithms for unstable systems requires high-quality, real-world data, yet access to specialized robotic hardware remains a significant barrier for many researchers. This paper introduces a comprehensive dynamics dataset for the Mini Wheelbot, an open-source, quasi-symmetric balancing...