arXiv preprints from January 1, 2026 through September 7, 2026 — 02:26:03 EST
Identifying and representing object instances such as cells or nuclei is a common task in microscopy image analysis. Established machine learning workflows typically use supervised detection or segmentation followed by feature extraction or classification, which requires manual annotations and treats instance segmentation and cell...
Large language models can describe mechanisms, yet scalable post-training still depends on costly, manually curated biological reasoning traces. Here we show that cellular perturbation atlases can instead become reinforcement-learning environments, where measured gene responses provide computable rewards for biological reasoning. We...
In clinical motor imagery brain-computer interface (MI-BCI) decoding, cross-day transferability and online operation remain two critical challenges. Hypergraphs can improve transferability by capturing higher-order sample relationships, yet existing hypergraph-based methods for online emotion recognition neglect the cross-day benefits...
The population structure of an inbred population of 781 people on Norfolk Island in the Pacific, 318 of which are descendants of the original Mutineers of the Bounty, is analyzed phenotypically using shape from stereo retinal fundus photographs. Three-dimensional optic nerve head (ONH) shape is reconstructed from stereo pairs by a...
Low-rank matrix decompositions can uncover patterns and structure in data and have a number of different applications across many disciplines. Extensions to "joint" low-rank decompositions have been proposed to link datasets from different modalities. While these methods enable the discovery of common patterns across modalities, they...
Generating photorealistic novel views from unposed images requires both 3D geometric understanding and the ability to synthesize unseen content. A natural strategy combines feed-forward 3DGS reconstruction with multi-view diffusion. Yet prior pipelines extract at most one signal from the reconstruction, either pixel rendering or...
We show how to compile an arbitrary classical circuit into a fault-tolerant circuit, which performs the desired computation even when an almost-linear number of bits are adversarially chosen and corrupted in each timestep. Using a variant of this fault-tolerance scheme that only detects (rather than corrects) corruptions, we give a...
A benchmark should deliver more than a scalar score: what makes an evaluation trustworthy is the reasoning that justifies the score. This is especially critical for world models, where judging a rollout requires understanding whether physics, causality, and world state evolve correctly. Humans spot such violations naturally, yet no...
Background Lung cancer remains the deadliest cancer worldwide because it is often diagnosed too late. Effective treatment depends on detection at an early screening stage. However, the growing number of patients and the limited number of radiologists lead to prolonged diagnostic waiting times. In very early stage lung cancer, nodule...
We show that, on trees, any locally checkable labeling problem (LCL) $Π$ that can be solved by an $n^{o(1)}$-dependent distribution can also be solved by an $O(\log n)$-round deterministic LOCAL algorithm. The result is obtained through a rake-and-compress-style decomposition of the input tree, and local simulations of the bounded...
Multi-segment suction-based soft robots are promising for inspection and maintenance in confined or fragile environments, but existing approaches still depend heavily on manually designed gaits and environment-specific motion scripts. This work presents a planning framework for serial multi-segment soft robots with deformable body...
Large Audio Language Models (LALMs) have made rapid progress on standardized benchmarks, yet their deployment in practical media workflows, curation, archival indexing, and content distribution remains largely unrealized. We identify automated audio chapterization, the task of segmenting continuous audio streams into thematically...
Modern power systems face growing operational complexity driven by the integration of renewable energy sources, decentralization, and the need for real-time decision-making across a wide range of timescales. Addressing these challenges traditionally relies on model-based methods that, while accurate, can be too slow for operational...
Allocation schemes that greedily maximize a readiness metric over the actuator fiber bundle of an overactuated multirotor produce commands that jump between disconnected optimal strata, demanding actuator rates no motor can deliver; effort-minimizing schemes are continuous but cannot guarantee that wrench-rate authority stays above...
Shared autonomy requires principled mechanisms for allocating and transferring control between a human and an autonomous agent. Existing approaches often rely on blending control inputs or heuristic switching rules, which lack theoretical guarantees and fail to account for the dynamics of authority transfer. This paper develops a...
Aggregate accuracy hides where models succeed and fail. Estimating conditional performance profiles from gold labels alone is expensive, while cheap auxiliary signals such as LLM-judge scores, pairwise comparisons, confidence scores, and judge-disagreement features can be collected for every benchmark item but are often biased or...
Group Independent Component Analysis (gICA) is widely used to decompose high-dimensional functional MRI data into interpretable brain networks. However, conventional gICA primarily identifies components shared across subjects. This group-level assumption can limit the recovery of networks present only in individuals or subject...
We initiate a polyhedral study of the graph multi-separator problem proposed by Irmai et al. (2024) as an alternative to the lifted multicut problem for application to the task of image segmentation. Starting with an integer linear program (ILP) formulation and the multi-separator polytope spanned by its feasible solutions, we...
Long-horizon robot manipulation chains many contact-rich skills into one multi-stage task. Vision-language-action (VLA) models increasingly master the individual skills, yet the chain still fails: errors compound beyond the policy's ability to correct, and one subtask silently constrains the next. A promising recipe freezes the VLA...
The development of safe and beneficial AI requires that systems can learn and act in accordance with human preferences. However, explicitly specifying these preferences by hand is often infeasible. Inverse reinforcement learning (IRL) addresses this challenge by inferring preferences, represented as reward functions, from expert...
This paper investigates an increasingly important topic in generative modeling: pixel-space diffusion models. Although numerous studies have explored this topic, most focus on small-scale or class-conditional settings. Consequently, a practical recipe for training pixel-space models that rival or exceed well-established latent-space...
Entrepreneurs increasingly use end-user generative AI technologies such as ChatGPT for high-stakes documents like loan applications and business plans, where AI-generated errors---a wrong price, a fabricated product---can affect loan or funding outcomes. Current approaches to supporting evaluation of AI-generated text assume a single...
Long-horizon robot manipulation requires a robot to both execute individual skills reliably and sequence them coherently over extended tasks. Most hierarchical vision-language-action (VLA) models make each such decision with a single forward pass, leaving no mechanism to allocate additional computation to difficult or consequential...
The current best bounds on the matrix multiplication exponent $ω$ are obtained through a refinement of the laser method called combination loss analysis (Duan et al., 2022; Williams et al., 2024; Alman et al., 2025). In this note, we address the optimization problem at the core of this approach and propose several improvements. First,...
This paper captures and extends some of the core results from the tech memo "A New Semantics for Belief Revision in Simplicial Complexes". As such, we set out to explore the implementation of action models in the setting of simplicial semantics for modal logic. Such an idea is not entirely new to the literature, showing up in both "A...