High-Order Epistasis Detection Using Factorization Machine with Quadratic Optimization Annealing and MDR-Based Evaluation
Detecting high-order epistasis is a fundamental challenge in genetic association studies due to the combinatorial explosion of candidate locus combinations. Although multifactor dimensionality reduction (MDR) is a widely used method for evaluating epistasis, exhaustive MDR-based searches become computationally infeasible as the number...