arXiv preprints from January 1, 2026 through September 5, 2026 — 12:09:11 EST
Deep generative models (DGMs) are widely used for complex high-dimensional data and increasingly applied to spatial and spatio-temporal modeling. Their generated samples implicitly represent the learned data distribution and associated uncertainty. However, for real-world data, assessing whether DGMs have learned the underlying...
Large-scale observational studies increasingly rely on AI pipelines to extract structured variables from unstructured clinical records. A common workflow separates the data vendor, who validates extraction accuracy with a gold-standard sample, from the downstream researcher, who receives only the extracted dataset and summary accuracy...
Meta-analyzing natural indirect effect estimates from multiple studies is increas- ingly used to synthesize evidence on causal pathways of interest. However, stan- dard mediation meta-analysis approaches are typically based on structural equation modeling, which fails to account for mediator-outcome confounding, is not read- ily...
Two-study meta-analyses are common in evidence synthesis but pose major statistical challenges. With only two studies, the between-study variance cannot be reliably estimated, rendering standard random-effects methods unstable. Here, we investigate meta-analyses based on Edgington's p-value combination method as an alternative...
The Expected Value of Sample Information (EVSI) is a powerful instrument to determine the value of additional evidence to inform an economic model. However, EVSI has been applied only to idealized data collection mechanisms, thereby reducing its potential applications in realistic studies. In this paper, we define a methodology to...
Many statistical problems concern the analysis of species distributions or, more generally, of discrete labeled quantities. Assessing species diversity constitutes a key step toward understanding population structure, and the Gini-Simpson index is among the most widely adopted diversity measures. In this manuscript, we examine several...
The framework of recanting twin path-specific effects has recently been propose to address the issue of intermediate confounding in causal mediation analysis, enabling the decomposition of the average treatment effect into identifiable fine-grained path-specific effects (PSEs). An open question, however, is the extent to which...
Generalised Bayesian inference (GBI) has emerged as a compelling robust alternative to standard Bayesian inference, mitigating sensitivity to data contamination by replacing the log-likelihood with a robust loss or divergence. However, existing robust GBI frameworks typically provide only qualitative robustness: while they can make...
The collective risk model is a fundamental framework in insurance ratemaking for modeling aggregate losses by combining claim frequency and claim severity components. A key structural requirement for a reliable experience rating system is a monotone ordering property: policyholders with worse past experience should receive a...
In the field of building energy efficiency, the measurement and verification (M&V) of energy savings following energy efficiency measures often relies on the use of a calibrated statistical model. In order to obtain reliable estimates, the estimation of uncertainties associated with this procedure is recognized as a crucial aspect of...
In meta-analyses of proportions, the event of interest is often rare, resulting in sparse event counts and frequent zero-event studies. The beta-binomial model has been used as a flexible random-effects model for pooling overdispersed and rare-event proportions. However, the commonly used maximum likelihood estimator (MLE) may be...
Item Response Theory (IRT) has recently been proposed as a framework for evaluating large language model (LLM) benchmarks by separating a model's latent ability from the properties of individual benchmark items. Existing neural IRT approaches, including PSN-IRT, estimate these quantities using point estimates, limiting uncertainty...
Classical regression approaches, including ordinary least squares, rely on strong assumptions such as constant variance and normality of residuals, which are often violated in real-world data. Although log-transformation is commonly used to stabilise variance, it may introduce re-transformation bias and fail to address...
The issue of model misspecification is critical, yet it is often regarded as unavoidable in applied statistical modeling. Model misspecification can be mitigated by incorporating informative features and strengthening model formulations, such as through the integration of domain knowledge or structural constraints. In this paper, we...
Standard offline reinforcement learning (RL) algorithms typically assume that the actions in the dataset are observed without error. However, in many real-world applications, the true actions are unobserved and only noisy proxies are available, causing existing RL methods to yield biased and potentially misleading conclusions. We...
Lloyd's $K$-means algorithm, also known as naïve $K$-means, is a widely used ad hoc optimization heuristic, designed to minimize the sum of squared errors (SSE) across all $K$-partitions of a dataset via iterative cluster refinement. In this work, we establish a novel connection between Lloyd's algorithm and the Frank-Wolfe (FW)...
High-dimensional data with sparse structure and spatio-temporal dependence arise in many scientific domains. We develop a Bayesian feature-extraction framework for spatio-temporal settings that employs Gaussian and Diffused-gamma priors to induce structured sparsity. The modeling framework specifies a general likelihood via Bregman...
Learning causal graphs from interventional data is a challenging problem with broad applications. In molecular biology, for example, a central goal is to uncover gene regulatory networks from large-scale perturbation data. An ideal algorithm for this task should scale to thousands of nodes, incorporate interventions even when their...
We establish a $\widetildeΩ(d^{5/4}\sqrt T)$ lower bound on the minimax expected regret of stochastic bandit convex optimization of $1$-Lipschitz functions on the Euclidean ball. This presents the first nontrivial regret lower bound that grows faster than $d\sqrt{T}$ for this problem, establishing that stochastic bandit convex...
Two-sample Mendelian randomization (MR) uses genetic variants as instrumental variables to estimate causal effects from observational data using summary association statistics. However, horizontal pleiotropy can invalidate standard MR estimators and lead to biased causal inference. Pleiotropy-robust methods have been proposed to...
Clinical trials for neurodegenerative diseases must identify sensitive endpoints -- outcomes that change rapidly enough to detect treatment effects. In Huntington disease, this requires measuring how outcomes change as participants approach Stage 1. Yet many participants exit studies before reaching this stage, making their time to...
Adaptive enrichment can allow the development of an experimental treatment to continue when its activity is insufficient in an all-comer population but remains promising in a prespecified biomarker-positive subgroup. However, a straightforward sequential application of separately calibrated phase II designs to the two populations can...
Gaussian graphical model selection is usually studied under independent sampling, but in many applications the data arise as a single trajectory of a dependent stochastic process. We study exact recovery of the graph from one trajectory of random-scan Gaussian Glauber dynamics. Existing techniques for this problem either inherit the...
Researchers often select top-performing options or winners, based on a data-driven criterion, such as treatments, models, or model features and then report effect estimates for the selected winners. Naive post-selection estimates, however, are known to suffer from the winner's curse, producing systematically overoptimistic results. We...
Gold-standard phenotype labels are often unavailable at scale in electronic health record (EHR) studies because they require manual chart review. Weakly supervised phenotyping methods instead use silver-standard labels, such as diagnosis-code counts, natural language processing (NLP) mentions, medication indicators, or laboratory...